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June 19, 2026Shengming kexue

Research progress on the impact of pre-analytical variables on RNA quality in biobank tissue samples

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Authors

YZYang-Si ZHENGXLXuan-Hao LINYWYuan-Yuan WANG

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Overview

Systematic review highlights how pre-analytical variables affect RNA quality, suggesting improved biobank protocols.

Key Points

  • This review aims to elucidate the impact of pre-analytical variables on RNA quality in biobank tissue samples.
  • Categorized pre-analytical variables into pre-acquisition and post-acquisition phases.
  • Examined factors such as donor characteristics, tissue factors, surgical variables, and preservation techniques.
  • Proposed standardized protocols for biobanks to enhance RNA integrity.
  • Identified critical pre-analytical factors influencing RNA quality, including warm ischemia time and freeze-thaw cycles.
  • Recommended full-chain temperature monitoring to mitigate quality degradation.
  • Highlighted the importance of applying standardized recording practices and RNA quality evaluation systems.

Cite This Study

ZHENG et al. (2026) studied this question.

synapsesocial.com/papers/6a34df4a65a5b0777af2e75ehttps://doi.org/10.3724/cbls.2026005
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