Overview uncovers Coenzyme Q's distribution and its protective role against ferroptotic cell death.
Coenzyme Q is a lipid first isolated from mitochondrial membranes in 1957. Despite seven decades of extensive study into its role in the electron transport chain, we are still uncovering the mechanisms that govern its transport from mitochondria, intracellular distribution, and functions beyond respiration. Here, we give a brief overview on recent findings on CoQ biology, focusing on its distribution and its role in ferroptotic cell death.
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Bhattacharya et al. (2026) studied this question.
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