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STED microscopy reveals protein dynamics and organization in cells, suggesting advancements in cellular imaging.
Cellular communication relies on precise protein trafficking, yet conventional microscopy lacks the resolution to visualize nanoscale structures. STED microscopy combined with CRISPR-Cas9 endogenous tagging using SNAP- and Halo-tags enables high-resolution imaging of protein dynamics in their native environment, revealing detailed organization of secretory compartments, endosomes, and immune signaling organization.
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Bregu et al. (2026) studied this question.
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