Randomized trial reveals nanoscale structures in cells using STED microscopy and CRISPR-tagging, indicating better imaging techniques for cellular studies.
Cellular communication relies on precise protein trafficking, yet conventional microscopy lacks the resolution to visualize nanoscale structures. STED microscopy combined with CRISPR-Cas9 endogenous tagging using SNAP- and Halo-tags enables high-resolution imaging of protein dynamics in their native environment, revealing detailed organization of secretory compartments, endosomes, and immune signaling organization.
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Bregu et al. (2026) studied this question.
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