August 15, 2025Open Access

Resolving protein organization in cells with nanometer resolution

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Ex-dSTORM achieves nanometer resolution, revealing detailed molecular organization in cells using standard methods.
Method demonstrates capability by resolving 8-nm periodicity in microtubules and clathrin structures.
Experimental verification included imaging RIM scaffolding proteins and Munc13-1 in hippocampal neurons.
Findings support the feasibility of investigating protein distributions with high spatial precision in live contexts.

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Expansion microscopy enhances dSTORM for studying protein organization in cells, revealing key structures in synapses.

Sauer et al. (2025) studied this question.

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