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June 19, 2026Clinical and Translational DiscoveryOpen Access

Epigenetic evolution of bladder cancer from cellular origin to clinical translation

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Authors

KQKaiyu QianZXZilin XuZCZhizhuang Chen

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Overview

Mini-review demonstrates epigenetic mechanisms impacting bladder cancer evolution, highlighting clinical applications.

Key Points

  • This work aims to synthesize recent findings on the epigenetic mechanisms driving bladder cancer progression and therapeutic resistance.
  • Reviewed studies combining single-cell chromatin accessibility profiling and DNA methylation analysis.
  • Analyzed how distinct urothelial cell populations contribute to bladder cancer subtypes.
  • Discussed translational outputs including a urine tumor DNA methylation assay and drug sensitivity screening.
  • Identified TM4SF1-positive subpopulations as key contributors to therapeutic resistance and cancer diversity.
  • Proposed molecular machinery sustaining cellular plasticity, including androgen receptor and FOXA1 interactions.
  • Validated a urine methylation assay for non-invasive cancer detection and monitoring.

Cite This Study

Qian et al. (2026) studied this question.

synapsesocial.com/papers/6a34dfcd65a5b0777af2ed85https://doi.org/10.1002/ctd2.70166
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tracing the evolution and progression of bladder cancer from epigenetic origins to clinical early diagnostics2026
  2. 2DNA Methylation in Bladder Cancer: Diagnostic and Therapeutic Perspectives—A Narrative Review2025 · 11 citations
  3. 3Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways2024
  4. 4Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma2024 · 7 citations
  5. 5Therapy-Driven Molecular Evolution of Bladder Cancer: Roles of Cellular Plasticity and Tumor Microenvironment2026 · 1 citations