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This review explores photodynamic therapy (PDT) as a non-antibiotic strategy for treating bacterial and fungal infections amid rising antimicrobial resistance.

June 19, 2026MicroOpen Access

Light-Activated Antimicrobial Agents and Biomaterials for Bacterial and Fungal Infections

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Authors

RMRostyslav MarunychRzeszów University DBDorota Bartusik‐AebisherRzeszów University BSBarbara SmolakRzeszów University

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Review analyzes photodynamic therapy strategies against bacterial and fungal infections, suggesting new treatment modalities.

Key Points

This review explores photodynamic therapy (PDT) as a non-antibiotic strategy for treating bacterial and fungal infections amid rising antimicrobial resistance.
Critical analysis of PDT mechanisms and selectivity towards microbial versus mammalian cells.
Comparison of various molecular photosensitizer classes and their delivery systems.
Examination of the role of nanoparticles and hydrogels in enhancing photosensitizer effectiveness.
PDT effectively induces oxidative damage to multiple microbial targets, reducing resistance likelihood.
Specific chemical interactions between photosensitizers and microbial membranes improve treatment efficacy.
Variable factors like light penetration and oxygen dependence critically influence PDT outcomes.

Cite This Study

Marunych et al. (2026) studied this question.

synapsesocial.com/papers/6a34e06865a5b0777af2f007 https://doi.org/10.3390/micro6020045

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Light-Activated Antimicrobial Agents and Biomaterials for Bacterial and Fungal Infections

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Light-Activated Antimicrobial Agents and Biomaterials for Bacterial and Fungal Infections

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Cite This Study

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