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August 5, 2026AntibioticsOpen Access

Strategies to Enhance the Efficacy and Clinical Translation of Antimicrobial Photodynamic Therapy

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Narrative review discusses strategies to improve antimicrobial photodynamic therapy efficacy and clinical application.

The research aims to explore strategies to enhance the efficacy and clinical translation of antimicrobial photodynamic therapy.
Summarized strategies including photosensitizer engineering and advanced light-source technologies.
Discussed hypoxia-modulating approaches and synergistic treatment strategies.
Highlighted challenges related to regulatory approval and clinical implementation.
Advanced systems improve bacterial targeting and biofilm penetration.
Enhanced reactive oxygen species generation and oxygen utilization are achieved.
Many approaches remain in preclinical stages due to safety and cost concerns.

Lin et al. (2026) studied this question.

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