Why the study?
The rising prevalence of MetS and GDM in women of reproductive age highlights their cardiometabolic risk, prompting investigation into whether relative abdominal adipose tissue distribution characterises metabolic risk beyond general adiposity.
Does relative abdominal adipose tissue distribution characterize metabolic risk beyond general adiposity in premenopausal Asian women?
Population
Premenopausal Asian women of reproductive age
Comparison
Abdominal adipose tissue distribution phenotypes derived from SSAT, DSAT, IPAT, and RPAT compartments
Design
Cohort study using magnetic resonance imaging
Key result
An abdominal fat distribution phenotype characterized by higher intraperitoneal and lower deep subcutaneous adipose tissue was associated with a 5.36-fold higher odds of developing gestational diabetes mellitus.
Authors
Loading...
Higher-risk adipose patterns may flag women needing closer GDM surveillance; leaves open independent predictive value and causal links.
Cohort (n=389)
Does relative abdominal adipose tissue distribution characterize metabolic risk beyond general adiposity in premenopausal Asian women?
Odds Ratio: 5.36 (95% CI 1.12–27.85)
Relative abdominal adipose tissue distribution, specifically higher intraperitoneal and lower deep subcutaneous fat, identifies premenopausal women at high risk for metabolic syndrome and gestational diabetes independent of overall adiposity.
Kway et al. (2026) conducted a cohort in Metabolic syndrome and Gestational diabetes mellitus (n=389). High %IPAT and low %DSAT abdominal fat phenotype (P1) vs. Low %IPAT and high %DSAT abdominal fat phenotype (P3) was evaluated on Gestational diabetes mellitus (GDM) (OR 5.36, 95% CI 1.12-27.85). An abdominal fat distribution phenotype characterized by higher intraperitoneal and lower deep subcutaneous adipose tissue was associated with a 5.36-fold higher odds of developing gestational diabetes mellitus.