What is the clinical evidence from this study?

Study design: Review. Population: Acute pulmonary embolism. Intervention: Early discharge and outpatient treatment.

What does this research mean for the field?

Early discharge and home-based anticoagulation for low-risk acute pulmonary embolism are supported by clinical guidelines and evidence, though real-world implementation remains heterogeneous. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The review aims to evaluate outpatient management strategies for acute pulmonary embolism (PE) with a focus on identifying low-risk patients for early discharge.

June 19, 2026VASAOpen Access

Early discharge and home treatment after acute pulmonary embolism

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Key result

Early discharge and home anticoagulation for low-risk PE face highly heterogeneous global implementation despite guidelines.

Why the study?

Implementation of early discharge and outpatient treatment strategies for acute PE remains highly heterogeneous across countries despite advances in risk stratification and direct oral anticoagulants.

Can low-risk patients with acute pulmonary embolism be safely managed with early discharge and home-based anticoagulation?

Population

Patients with acute pulmonary embolism

Design

Review

Authors

LHLukas HobohmInterventional Cardiology GTGiacomo TurattiAzienda Ospedale - Università Padova BMBenedetta MadaroUniversity of Insubria

Discussion

Member takes

Implication

Refined risk stratification enables safe outpatient PE management in stable patients; extends 2019 ESC guidance on level-of-care decisions.

Key Points

The review aims to evaluate outpatient management strategies for acute pulmonary embolism (PE) with a focus on identifying low-risk patients for early discharge.
Synthesized evidence from current clinical guidelines and literature on outpatient treatment for acute PE.
Emphasized risk stratification strategies and cost-effectiveness of early discharge protocols.
Reviewed contemporary guidelines from the European Society of Cardiology regarding management of acute PE.
Identified low-risk patients could be safely discharged within 24–48 hours post-admission.
Highlighted the role of direct oral anticoagulants in enabling safer outpatient treatment and reducing hospital stays.
Noted the variability in outpatient treatment strategies across different countries due to healthcare system differences.

Structured PICO

Can low-risk patients with acute pulmonary embolism be safely managed with early discharge and home-based anticoagulation?

Population

Patients with acute pulmonary embolism, specifically hemodynamically stable, low-risk patients

Intervention

Early discharge (within 24-48 h) and home-based anticoagulation (including direct oral anticoagulants)

This review synthesizes current evidence on risk-stratification and outpatient management of acute pulmonary embolism, supporting early discharge for low-risk patients.

Cite This Study

Hobohm et al. (2026) conducted a review in Acute pulmonary embolism. Early discharge and outpatient treatment was evaluated. Early discharge and home-based anticoagulation for low-risk acute pulmonary embolism are supported by guidelines, though implementation remains highly heterogeneous across countries.

synapsesocial.com/papers/6a35982fdd3be7785e70ecd7 https://doi.org/10.1024/0301-1526/a001296

Topics

Pulmonary embolism Anticoagulation in AF

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Implication

Refined risk stratification enables safe outpatient PE management in stable patients; extends 2019 ESC guidance on level-of-care decisions.

Early discharge and home treatment after acute pulmonary embolism

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Early discharge and home treatment after acute pulmonary embolism

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider