Low-dose aspirin use in pregnancy may be associated with an increased risk of bleeding, highlighting the need to consider discontinuing aspirin prior to delivery.
Does continuation of low-dose aspirin until delivery increase bleeding and hemorrhage risk in pregnant women at high risk of preeclampsia?
This review highlights the potential bleeding risks of continuing low-dose aspirin until delivery in pregnant women, suggesting consideration for its discontinuation prior to delivery.
Low-dose aspirin is recommended by nearly every major obstetric society for women at high risk of preeclampsia. There is consistent and robust data surrounding preeclampsia prevention, particularly severe early-onset disease; however, there are signals in the data that question the safety of continuation until delivery due to potential increased risk of bleeding. There is robust data from the non-pregnant population that demonstrates concern with long-term aspirin use and bleeding risk. The obstetric literature lacks such robust studies around bleeding concerns, particularly around the time of delivery in individuals using aspirin in pregnancy. This review provides a comprehensive, review of bleeding and hemorrhage risk associated with aspirin use in pregnancy and highlights the consideration for aspirin discontinuation prior to delivery.
Sullivan et al. (Mon,) conducted a review in Pregnancy at high risk of preeclampsia. Low-dose aspirin was evaluated on Bleeding and hemorrhage risk. Low-dose aspirin use in pregnancy may be associated with an increased risk of bleeding, highlighting the need to consider discontinuing aspirin prior to delivery.