Key result
Sympathetic hyperactivity is a prevalent characteristic in patients with chronic kidney disease that has significant clinical relevance and implications for treatment choices.
This review summarizes the pathogenesis, clinical relevance, and treatment implications of sympathetic hyperactivity in patients with chronic kidney disease.
Supports sympathetic modulation as a CKD target; leaves open need for RCTs before practice change.
Chronic kidney disease is often characterized by the presence of sympathetic hyperactivity. The aim of this brief review is to summarize available knowledge on the pathogenesis of sympathetic hyperactivity and to discuss its clinical relevance, the consequences of this knowledge for the choice of treatment, and the yet unresolved issues.
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Peter J. Blankestijn (2007) studied this question. Sympathetic hyperactivity is a prevalent characteristic in patients with chronic kidney disease that has significant clinical relevance and implications for treatment choices.
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