This review highlights the central role of the kidneys in sympathetic hyperactivity and discusses renal denervation as a potential therapeutic option for conditions like hypertension and heart failure.
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Renal denervation may warrant consideration in sympathetic-driven hypertension and HF; leaves open confirmation in large randomized outcome trials.
Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload - such as heart failure - and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.
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Vink et al. (2012) studied this question.
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