Key result
Sympathetic overactivity in chronic renal failure is caused by neurohormonal mechanisms arising in the failing kidney, contributing to hypertension.
Population
Patients with chronic renal failure and hypertension
Design
Review
Authors
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Renal afferent modulation may warrant exploration in CRF hypertension; extends mechanistic data but remains hypothesis-generating without interventional trials.
Highlights the role of sympathetic overactivity, driven by renal afferents, in the pathogenesis of hypertension in chronic renal failure.
Augustyniak et al. (2002) conducted a review in Hypertension in chronic renal failure. Sympathetic overactivity was evaluated. Sympathetic overactivity in chronic renal failure is caused by neurohormonal mechanisms arising in the failing kidney, contributing to hypertension.
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