Key result
In 330 patients with ATTR-CA (16% female), indexing left ventricular wall thickness by height^2.7 more accurately reflected cardiac disease severity than non-indexed values.
Why the study?
Because normal LV wall thickness is lower in women, using the same cut-off value for men and women could lead to underdiagnosis or delayed diagnosis of cardiac amyloidosis in women.
Does indexing left ventricular wall thickness by body size metrics improve correlation with cardiac disease severity in patients with ATTR-CA compared to non-indexed values?
Observational (n=330)
Yes
Does indexing left ventricular wall thickness by body size metrics improve correlation with cardiac disease severity in patients with ATTR-CA compared to non-indexed values?
Indexing left ventricular wall thickness by height^2.7 more accurately reflects the severity of cardiac involvement in ATTR-CA than non-indexed values, accounting for sex differences in body size.
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Indexed LV thickness may better gauge ATTR-CA severity by gender; leaves open validation for diagnostic thresholds.
Aimo et al. (2023) conducted an observational in Transthyretin (ATTR) cardiac amyloidosis (n=330). Indexed left ventricular wall thickness (by height^2.7) vs. Non-indexed left ventricular wall thickness was evaluated on Correlation with indicators of cardiac disease severity (NT-proBNP, relative wall thickness, E/e' ratio, TAPSE). In 330 patients with ATTR-CA (16% female), indexing left ventricular wall thickness by height^2.7 more accurately reflected cardiac disease severity than non-indexed values.
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