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June 14, 2026Heart Rhythm O2Open Access

Left Ventricular Wall Thickness on Systolic-Phase Pulmonary Vein CT as a Marker for Cardiac Amyloidosis

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To evaluate if left ventricular wall thickness on systolic-phase pulmonary vein CT can identify cardiac amyloidosis.
Retrospective analysis of 160 patients undergoing pulmonary vein CT for atrial fibrillation ablation planning.
80 patients confirmed with cardiac amyloidosis and 80 matched controls were included.
Left ventricular septal wall thickness measured using multiplanar reconstruction techniques.
Patients with cardiac amyloidosis had higher mean septal thickness (22.3 ± 3.5 mm) compared to controls (14.9 ± 2.5 mm, p<0.001).
Logistic regression identified combined septal thickness as an independent predictor of cardiac amyloidosis (OR 1.78, 95% CI 1.43–2.21, p<0.001).
ROC analysis yielded an excellent performance (AUC 0.964, 95% CI 0.939–0.988, p<0.001) with 36 mm as the optimal cutoff for diagnosis.

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Randomized trial shows increased LV wall thickness in patients with cardiac amyloidosis, suggesting early diagnosis potential.

Zalaquett et al. (2026) studied this question.

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