Key result
Premature ventricular contractions during apneic events showed significantly different turbulence onset (21.75% vs 31.96%, p<0.0008) and slope on a per-PVC basis compared to normal breathing.
Why the study?
Current assessment of OSA severity using the apnea hypopnea index does not reflect how OSA affects cardiovascular system health.
Do premature ventricular contractions during apneic events result in different heart rate turbulence metrics compared to those during normal breathing in patients with obstructive sleep apnea?
Comparison
PVCs during apneic events vs during normal breathing
Design
Observational study
Authors
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May identify apnea-specific autonomic effects via PVC turbulence; hypothesis-generating for ECG-derived OSA severity metrics beyond AHI.
Observational (n=11)
Do premature ventricular contractions during apneic events result in different heart rate turbulence metrics compared to those during normal breathing in patients with obstructive sleep apnea?
Absolute Event Rate: 21.75% vs 31.96%
p-value: p=<0.0008
Nocturnal PVCs mediate quantifiably different disruptions in heart rate turbulence depending on whether they occur during apneic events or normal breathing in patients with OSA.
Askari et al. (2022) conducted an observational in Obstructive Sleep Apnea (n=11). Apneic events vs. Normal breathing periods was evaluated on Turbulence onset (TO) computed for each premature ventricular contraction (p=<0.0008). Premature ventricular contractions during apneic events showed significantly different turbulence onset (21.75% vs 31.96%, p<0.0008) and slope on a per-PVC basis compared to normal breathing.
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