Key result
Higher physical activity links to lower white blood cell counts and improved HRV.
Why the study?
The study aimed to identify associations between clinical inflammatory risk markers, body composition, HRV, and self-reported and objectively assessed physical activity in university students with overweight and obesity.
Does physical activity level correlate with inflammatory risk markers and heart rate variability in university students with overweight and obesity?
Cross-Sectional (n=17)
Randomized crossover sequence for trial visits
No
Does physical activity level correlate with inflammatory risk markers and heart rate variability in university students with overweight and obesity?
In overweight and obese university students, higher fat mass correlates with increased inflammatory markers, whereas light to moderate-to-vigorous physical activity is associated with improved parasympathetic regulation and anti-inflammatory benefits.
Associations in small student sample warrant interpretive caution; leaves open prospective validation of activity-HRV and adiposity-inflammation links.
This cross-sectional study aimed to identify associations between clinical inflammatory risk markers, body composition, heart rate variability (HRV), and self-reported and objectively assessed physical activity (PA) in university students with overweight and obesity. Seventeen participants (eight females) completed a screening visit following a randomized controlled four-arm crossover trial period with 8 h of uninterrupted prolonged sitting, alternate sitting and standing, continuous standing, and continuous slow walking, respectively. Clinical inflammatory risk markers were obtained from venous blood samples, and PA was assessed using the International Physical Activity Questionnaire (IPAQ-SF) and ActiGraph wGT3X-BT accelerometers. HRV was recorded over 24 h using the Faros 180 Holter electrocardiogram (ECG). White blood cell (WBC) counts were significantly correlated with fat mass (FM; p = 0.03) and visceral adipose tissue (VAT; p = 0.04) and inversely correlated with moderate PA (p = 0.02). Light-intensity PA (LIPA) and moderate-to-vigorous PA (MVPA) were correlated with HRV parameters (p = 0.02), and LIPA was inversely correlated with interleukin-6 (p = 0.003) and c-reactive protein (p = 0.04) during different trial conditions. In university students with overweight and obesity, higher values of FM were negatively correlated with WBC count, and integrating LIPA and MVPA in the students’ daily life strengthened their sympathetic–parasympathetic regulation and positively mediated anti-inflammatory mechanisms.
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Hoffmann et al. (2025) conducted a cross-sectional in Overweight and obesity (n=17). Physical activity (LIPA, MVPA) and 4 activity conditions (sitting, sitting/standing, standing, walking) was evaluated on Associations between clinical inflammatory risk markers, body composition, heart rate variability, and physical activity. White blood cell counts correlated with fat mass (p=0.03) and inversely with moderate physical activity (p=0.02), while light-intensity and moderate-to-vigorous physical activity were correlated with HRV parameters (p=0.02).
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