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June 20, 2026Frontiers in ImmunologyOpen Access

Exosomal microRNAs in colorectal cancer communication networks: implications for metastasis, therapy resistance, and precision medicine

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Authors

AMAshutosh Kumar MauryaSMSheefa Mirza

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Overview

Review explores how exosomal miRNAs in colorectal cancer affect metastasis and therapy resistance, suggesting new approaches for precision medicine.

Key Points

  • The aim is to highlight the role of exosomal microRNAs in intercellular communication and their impact on metastasis and therapy resistance in colorectal cancer.
  • Reviewed current knowledge on exosome biogenesis and selective miRNA sorting.
  • Analyzed communication within the tumor microenvironment and its relation to therapy resistance.
  • Highlighted emerging approaches like systems biology and artificial intelligence for biomarker improvement.
  • Exosomal miRNAs play a crucial role in regulating pathways involved in metastasis and drug resistance.
  • High biological stability of exosomal miRNAs in blood plasma suggests promising liquid biopsy applications.
  • Challenges in clinical translation include extracellular vesicle heterogeneity and lack of standardization.

Cite This Study

Maurya et al. (2026) studied this question.

synapsesocial.com/papers/6a362d32db0793dc1a535a4ehttps://doi.org/10.3389/fimmu.2026.1872130
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