What question did this study set out to answer?

This study aims to evaluate the effectiveness of recombinant human bone morphogenetic protein-2 (rhBMP-2) in reconstructing alveolar clefts.

The effectiveness of using recombinant human bone morphogenetic protein-2 in the reconstruction of alveolar clefts: a meta-analysis

View Full Paper

Ask AI

Bookmark

This study aims to evaluate the effectiveness of recombinant human bone morphogenetic protein-2 (rhBMP-2) in reconstructing alveolar clefts.
Databases searched include PubMed, Embase, Web of Science, Scopus, and Cochrane until April 2024.
Studies compared the effectiveness of rhBMP-2 and autologous iliac bone in osteogenesis for alveolar clefts.
Six studies focusing on bone formation rate, volume, density, and complications were included.
Autologous iliac bone graft showed significantly higher bone formation (MD −14.54; 95% CI −21.58 to −7.49; p < 0.0001) after 6 months.
Bone density was lower with rhBMP-2 after 6 (MD 186.60; 95% CI 33.26–339.94; p = 0.02) and 12 months (MD 188.70; 95% CI 25.13–352.27; p = 0.02).
No significant differences in postoperative complications between rhBMP-2 and autologous grafts (MD 0.67; 95% CI 0.25–1.78; p = 0.42).

No takes yet. Share an insight, caveat, or question.

Meta-analysis examines bone reconstruction outcomes using rhBMP-2 versus autologous bone grafts in alveolar clefts, suggesting limited benefits.

Xu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Meta-analysis examines bone reconstruction outcomes using rhBMP-2 versus autologous bone grafts in alveolar clefts, suggesting limited benefits.