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July 20, 2026BMC Oral HealthOpen Access

BMP-2 in oral-maxillofacial bone augmentation: a systematic review and meta-analysis

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Authors

GYGuangzheng YangShanghai Jiao Tong UniversityYXY X XiaLishui Central HospitalWSWentao ShiBeihua University

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Implication

Systematic review evaluates BMP-2 for bone augmentation in oral-maxillofacial procedures, suggesting modest benefits.

Key Points

  • This study evaluates the efficacy and safety of BMP-2 in oral and maxillofacial bone augmentation procedures based on randomized controlled trials.
  • Conducted a systematic review of randomized controlled trials (RCTs) involving BMP-2 in bone augmentation procedures.
  • Assessment of risk of bias using the Cochrane risk-of-bias 2 tool; meta-analyses and subgroup analyses performed.
  • Included 23 RCTs involving 990 participants and 1104 sites, searching seven databases up to May 1, 2026.
  • BMP-2 significantly increased alveolar ridge width at the apical region.
  • No significant enhancement in the proportion of new bone or reduction in residual graft material observed.
  • Implant survival rates and incidence of adverse events showed no significant differences between groups.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a5dbad58bd453d3397abf81https://doi.org/10.1186/s12903-026-09127-3
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