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This research investigates the oncogenic potential of a murine C-type RNA virus derived from tumors in BALB/cCr mice.

Oncogenic Potential of Murine C-Type RNA Virus Passaged Directly from Naturally Occurring Tumors of the BALB/cCr Mouse

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Randomized trial demonstrates oncogenic virus induction in BALB/cCr mice, suggesting viral involvement in tumorigenesis.

This research investigates the oncogenic potential of a murine C-type RNA virus derived from tumors in BALB/cCr mice.
Inoculated 1954 BALB/cCr mice at birth with 141 viral preparations from spontaneous tumors.
Observed over a period of 24 months for tumor induction and classification.
Analyzed the relation between tumor histology and resultant neoplasms.
51% of tumors yielded isolatable virus and induced lympho-reticular neoplasms in virus-positive inocula (P<0.05).
No solid non-lympho-reticular neoplasms were induced by the virus.
The mean latent period for LR neoplasm induction was 469 days, shorter than the natural occurrence of 634 days.

Peters et al. (1973) studied this question.

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