What question did this study set out to answer?

Investigate whether the timing of endogenous ecotropic retrovirus activation correlates with lymphoma latency, incidence, and pathology, and characterize retroviruses present in tumor tissues.

December 1, 1981JNCI Journal of the National Cancer Institute

Spontaneous Lymphomas in SJL/J-(v+) Mice: Ecotropic and Dualtropic Virus Expression in Normal and Lymphomatous Tissues 2 3

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Authors

ARAnita De RossiUniversity of Padua EDEmma D’AndreaMount Sinai Hospital ACAlfonso ColombattiCentro di Riferimento Oncologico

Discussion

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Implication

Early virus activation in SJL mice warrants no clinical action; leaves open timing as a determinant of lymphoma latency in retroviral models.

Key Points

Investigate whether the timing of endogenous ecotropic retrovirus activation correlates with lymphoma latency, incidence, and pathology, and characterize retroviruses present in tumor tissues.
Assayed tail tissues of 57 1- and 2-month-old SJL/J-(v+) mice for endogenous ecotropic XC+ virus to evaluate activation timing, followed by longitudinal monitoring for lymphoma development.
Quantified virus titers and viral protein content in both normal and lymphomatous organs of diseased mice.
Tested normal and lymphomatous mice for XC- viruses using mink lung cells, followed by limiting dilution cloning, cytopathic effect evaluation, interference assays, and neutralization assays.
At 1 month of age, 63% of mice expressed ecotropic virus, and 100% did by 2 months, but early versus late activation showed no correlation with lymphoma incidence, latency, or histopathology.
Lymphomatous organs exhibited markedly lower XC+ virus titers than tail tissues, with a lack of close correlation between viral protein content and infectious virus titers.
Mink lung cell-tropic viruses were detected in only 1 of 6 aged normal mice compared to 16 of 19 lymphomatous mice, yielding isolates identified as dualtropic mink cell focus-forming-like viruses.

Cite This Study

Rossi et al. (1981) studied this question.

synapsesocial.com/papers/6a917fa82d14ef2b6ea16834 https://doi.org/10.1093/jnci/67.6.1241

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Implication

Early virus activation in SJL mice warrants no clinical action; leaves open timing as a determinant of lymphoma latency in retroviral models.

Spontaneous Lymphomas in SJL/J-(v+) Mice: Ecotropic and Dualtropic Virus Expression in Normal and Lymphomatous Tissues 2 3

Discussion

Member takes

Implication

Key Points

Cite This Study

Spontaneous Lymphomas in SJL/J-(v+) Mice: Ecotropic and Dualtropic Virus Expression in Normal and Lymphomatous Tissues 2 3

Discussion

Member takes

Implication

Key Points

Cite This Study

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