What question did this study set out to answer?

To assess the role of recombinant mink cell focus-inducing (MCF) murine leukemia viruses in spontaneous thymic lymphoma and identify host genetic factors influencing disease occurrence in AKR F1 hybrids.

August 1, 1983The Journal of Experimental MedicineOpen Access

Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids.

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Authors

WRWallace P. RoweNew York State Department of Health JHJanet W. HartleyNational Institute of Allergy and Infectious Diseases

Discussion

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Implication

Genetic cross study reveals multiple host genes controlling retroviral infection and thymic lymphomagenesis in AKR hybrid mice, highlighting complex genetic resistance to viral oncogenesis.

Key Points

To assess the role of recombinant mink cell focus-inducing (MCF) murine leukemia viruses in spontaneous thymic lymphoma and identify host genetic factors influencing disease occurrence in AKR F1 hybrids.
Generated F1 hybrid crosses between high-leukemic AKR mice and various inbred mouse strains.
Evaluated spontaneous lymphoma incidence, MCF virus frequency, and preleukemic thymocyte antigenic amplification.
Inoculated neonates with MCF 247 virus to test susceptibility to experimentally induced lymphoma.
MCF virus detection frequency, preleukemic thymocyte antigenic amplification, and spontaneous lymphoma incidence showed close qualitative correlation across hybrid crosses.
Hybrids with moderate-to-high spontaneous lymphoma incidence were uniformly susceptible to neonatal MCF 247 virus induction, whereas low-leukemic hybrids exhibited partial resistance.
Identified at least four distinct host resistance genes restricting pathogenesis: Fv-1, Rmcf, an unidentified gene in C57 and SJL strains, and an unidentified minor gene in other inbred strains.

Cite This Study

Rowe et al. (1983) studied this question.

synapsesocial.com/papers/6a99d4441cdebc412a558923 https://doi.org/10.1084/jem.158.2.353

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Implication

Genetic cross study reveals multiple host genes controlling retroviral infection and thymic lymphomagenesis in AKR hybrid mice, highlighting complex genetic resistance to viral oncogenesis.

Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids.

Discussion

Member takes

Implication

Key Points

Cite This Study

Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids.

Discussion

Member takes

Implication

Key Points

Cite This Study

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