What question did this study set out to answer?

To determine the incidence and types of spontaneous neoplasms in NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci compared to virus-negative controls.

August 1, 1984JNCI Journal of the National Cancer Institute

Spontaneous Tumors of NFS Mice Congenic for Ecotropic Murine Leukemia Virus Induction Loci2

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Authors

TFTorgny N. FredricksonNational Institute of Allergy and Infectious Diseases HMHerbert C. MorseNational Institute of Allergy and Infectious Diseases WRWallace P. RoweNew York State Department of Health

Discussion

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Implication

Comparative animal study reveals increased hematopoietic neoplasms in mice carrying murine leukemia virus loci, indicating high systemic viral expression drives diverse spontaneous tumors.

Key Points

To determine the incidence and types of spontaneous neoplasms in NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci compared to virus-negative controls.
Evaluated spontaneous tumor development in NFS/N mice congenic for ecotropic MuLV induction loci derived from AKR and C58 mouse strains.
Compared tumor incidence, tumor spectrum, and latency between congenic mice, virus-negative NFS/N controls, and AKR/N or C58/Lw donor strains.
NFS V-congenic mice developed thymic lymphomas whereas virus-negative NFS/N mice developed none, though congenics had lower lymphoma frequencies and longer latency periods than AKR/N or C58/Lw donor mice.
Frequencies of nonthymic lymphomas and myelogenous leukemias increased more than threefold in congenic mice relative to NFS/N controls.
Higher frequencies of hematopoietic neoplasms in congenic strains were associated with early systemic expression of high ecotropic MuLV levels.

Cite This Study

Fredrickson et al. (1984) studied this question.

synapsesocial.com/papers/6a7e6785dea41f5fbab7b720 https://doi.org/10.1093/jnci/73.2.521

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Implication

Comparative animal study reveals increased hematopoietic neoplasms in mice carrying murine leukemia virus loci, indicating high systemic viral expression drives diverse spontaneous tumors.

Spontaneous Tumors of NFS Mice Congenic for Ecotropic Murine Leukemia Virus Induction Loci2

Discussion

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Implication

Key Points

Cite This Study

Spontaneous Tumors of NFS Mice Congenic for Ecotropic Murine Leukemia Virus Induction Loci2

Discussion

Member takes

Implication

Key Points

Cite This Study

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