Population
Mouse strains (AKR, C58, CE/J, AKXD recombinant inbred strains)
Comparison
Infection with ecotropic murine leukemia virus… vs Mice without ecotropic MuLV infection, mice…
Design
Preclinical
Authors
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Identifies MuLV as a key cofactor for LDV-induced paralysis in mice; leaves open relevance to human motor neuron disease.
Ecotropic MuLV infection of spinal cord cells renders anterior horn neurons susceptible to cytocidal LDV infection, explaining the genetic linkage to paralytic disease in specific mouse strains.
Anderson et al. (1995) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: