Key result
LDV replicated in continuous mouse and rat cell lines infected with an ecotropic MuLV but not in uninfected cells, with the neurovirulent LDV-C strain showing 50- to 100-fold greater infectivity.
Population
Continuous mouse and rat cell lines infected with ecotropic murine leukaemia virus isolated from C58 mice…
Comparison
Infection with lactate dehydrogenase-elevating… vs Cells not infected with MuLV
Design
Preclinical
Authors
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Enables in vitro modeling of LDV neurovirulence; leaves open translation to human retroviral disease.
LDV replication in vitro is facilitated by prior MuLV infection, with neurovirulent strains showing significantly higher infectivity to these cells, potentially explaining the mechanism of LDV-induced paralytic disease.
Inada et al. (1991) studied Lactate dehydrogenase-elevating virus (LDV) infection. Murine leukaemia virus (MuLV) infection vs. Cells not infected with MuLV was evaluated on LDV replication and infectivity. LDV replicated in continuous mouse and rat cell lines infected with an ecotropic MuLV but not in uninfected cells, with the neurovirulent LDV-C strain showing 50- to 100-fold greater infectivity.
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