Key result
Lactate dehydrogenase-elevating virus infection in C58/J mice caused specific ultrastructural changes in anterior horn neurons that were not immune mediated.
Population
Young and 18-month-old C58/J mice
Design
Preclinical
Authors
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Hypothesis-generating for non-immune viral motor neuron injury; human relevance remains untested.
LDV-C-induced nonparalytic poliomyelitis cytopathology in mice is characterized by specific ultrastructural changes in anterior horn neurons and is not immune-mediated.
Stroop et al. (1985) studied Lactate dehydrogenase-elevating virus-induced nonparalytic poliomyelitis. Lactate dehydrogenase-elevating virus (LDV-C) and cyclophosphamide was evaluated on Ultrastructural and immunofluorescent changes in anterior horn neurons. Lactate dehydrogenase-elevating virus infection in C58/J mice caused specific ultrastructural changes in anterior horn neurons that were not immune mediated.
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