Key result
The ADPE agent was identified as a strain of lactate dehydrogenase-elevating virus (LDV), exhibiting indistinguishable morphologies, replication kinetics, and strong antigenic cross-reactivity.
Population
Mice (including immunosuppressed C58 mice) and primary mouse macrophages
Comparison
Genetically restricted, age-dependent… vs Lactate dehydrogenase-elevating virus isolates
Design
Preclinical
Authors
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Resolves etiology in this murine model; leaves open translation to human CNS disease and mechanisms of age/genetic restriction.
The etiological agent of genetically restricted, age-dependent polioencephalomyelitis of mice is identified as a strain of lactate dehydrogenase-elevating virus.
Martínez et al. (1980) studied genetically restricted, age-dependent polioencephalomyelitis of mice. ADPE agent vs. Lactate dehydrogenase-elevating virus (LDV) isolates was evaluated. The ADPE agent was identified as a strain of lactate dehydrogenase-elevating virus (LDV), exhibiting indistinguishable morphologies, replication kinetics, and strong antigenic cross-reactivity.
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