Key result
C58 mice had tenfold higher plasma LDV titres and twice the proportion of LDV-permissive macrophages than resistant strains, despite normal humoral immune responses.
Population
C58 mice and mice of various resistant strains
Comparison
Infection with lactate dehydrogenase-elevating… vs Mice of various resistant strains
Design
Preclinical
Follow-up
1 to 2 weeks post-infection
Authors
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Macrophage permissiveness, not humoral defects, drives LDV sensitivity in C58 mice; leaves open mechanisms of paralytic disease.
The sensitivity of C58 mice to LDV-induced paralytic disease is not due to an inherent inability to mount a humoral antibody response, but is associated with higher viral replication and permissive macrophage proportions.
Cafruny et al. (1986) studied Lactate dehydrogenase-elevating virus (LDV) infection. Lactate dehydrogenase-elevating virus (LDV) infection vs. Resistant mouse strains was evaluated on Plasma and tissue LDV titres and humoral immune response. C58 mice had tenfold higher plasma LDV titres and twice the proportion of LDV-permissive macrophages than resistant strains, despite normal humoral immune responses.
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