Key result
Neuropathogenic LDV-C and nonneuropathogenic LDV-P coexist in virus pools, and LDV-C exhibits a reduced ability to establish persistent infection in peripheral tissues compared to LDV-P.
Population
Immunosuppressed C58 and AKR mice, and other mouse strains
Design
Preclinical
Authors
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May limit neuropathogenic spread via antibody sensitivity; leaves open mechanisms of variant selection in animal models.
Neuropathogenic LDV variants have a reduced ability to establish persistent infection in peripheral tissues compared to nonneuropathogenic variants, likely due to higher sensitivity to antibody neutralization.
Chen et al. (1997) studied Lactate dehydrogenase-elevating virus (LDV) infection. Lactate dehydrogenase-elevating virus (LDV) variants (LDV-C and LDV-P) was evaluated on Coexistence and persistence of LDV variants. Neuropathogenic LDV-C and nonneuropathogenic LDV-P coexist in virus pools, and LDV-C exhibits a reduced ability to establish persistent infection in peripheral tissues compared to LDV-P.
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