Population
Mitogen-stimulated murine lymphocyte cultures from different mouse strains (NFS/N, 129, BALB/c, AKR)
Design
Preclinical
Authors
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Supports defective provirus encoding of endogenous retroviruses in mice; hypothesis-generating and requires in vivo confirmation before any translational consideration.
The findings indicate that non-infectious endogenous mouse viruses are encoded by defective proviruses rather than resulting from faulty host cell-controlled virus maturation.
Stoye et al. (1984) studied this question.
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