June 1, 1975Journal of VirologyOpen Access

Nucleic acid homology of murine xenotropic type C viruses

View Full Paper

Ask AI

Bookmark

Population

Murine xenotropic type C viruses isolated from various mouse strains

Design

Preclinical

Authors

RCRobert CallahanNational Institutes of Health MLMichael M. LieberRutgers, The State University of New Jersey GTGeorge J. TodaroLawrence Livermore National Laboratory

Discussion

Member takes

Implication

Animal data distinguish xenotropic virus subclasses; leaves open the functional significance of endogenous virogene polymorphism in mice.

Structured PICO

Population

Murine xenotropic type C viruses isolated from various mouse strains (BALB/c, C57BL/6J, C58/J, AKR/J, CBA/J, DBA/2J, NIH Swiss, NZB/BINJ, and Mus musculus molossinus)

Intervention

Nucleic acid hybridization using [3H]DNA transcripts of viral RNA

Outcome

Degree of relatedness of hybridized nucleic acid sequences (final extents of hybridization and thermal stability/Tm)surrogate

Nucleic acid hybridization distinguishes two major subclasses of xenotropic murine type C viruses, suggesting significant polymorphism among endogenous virogenes of Mus musculus.

Cite This Study

Callahan et al. (1975) studied this question.

synapsesocial.com/papers/6a8c2d710ca85c7e33df2f9c https://doi.org/10.1128/jvi.15.6.1378-1384.1975

View Full Paper

Ask AI

Bookmark

Nucleic acid homology of murine xenotropic type C viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nucleic acid homology of murine xenotropic type C viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider