Genetic recombination between mouse type C RNA viruses: a mechanism for endogenous viral gene amplification in mammalian cells.
Population
Mammalian cells and mouse type C RNA viruses (exogenous and endogenous)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Indicates recombinational origin of inducible xenotropic viruses in mice; leaves open applicability to human endogenous retroviruses.
Structured PICO
P
Population
Mammalian cells and mouse type C RNA viruses (exogenous and endogenous)
I
Intervention
Identification of type-specific antigenic determinants in the transitional products of gag, pol, and env genes
O
Outcome
Genetic recombination and relationships between different classes of endogenous virussurrogate
The inducible xenotropic virus of mouse cells likely arose by a recombinational mechanism involving the progenitors of the other two endogenous virus classes.
Cite This Study
Barbacid et al. (1978) studied this question.