Induction of mouse type-C virus by translational inhibitors: evidence for transcriptional derepression of a specific class of endogenous virus.
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Population
Mouse embryo cells of different genotypes (BALB/c, NIH Swiss, NZB, wild mouse, and F1 hybrids)
Comparison
Translational inhibitors vs Untreated cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Translational inhibitors may activate endogenous retroviruses in animal models; leaves open relevance to human cells or disease.
Structured PICO
P
Population
Mouse embryo cells of different genotypes (BALB/c, NIH Swiss, NZB, wild mouse, and F1 hybrids)
I
Intervention
Translational inhibitors (cycloheximide, pactamycin, puromycin)
C
Comparator
Untreated cells
O
Outcome
Cellular concentration of virus-specific RNA and subsequent induction of virussurrogate
Translational inhibitors induce endogenous mouse type-C virus by transcriptional derepression rather than post-transcriptional stabilization.
Cite This Study
Cabradilla et al. (1976) studied this question.
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