February 1, 1974Science
High-Frequency C-Type Virus Induction by Inhibitors of Protein Synthesis
Population
BALB/c mouse cells in culture
Comparison
Inhibitors of protein synthesis vs Halogenated pyrimidines
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications; leaves open extension of murine retroviral induction models to humans.
Structured PICO
P
Population
BALB/c mouse cells in culture
I
Intervention
Inhibitors of protein synthesis
C
Comparator
Halogenated pyrimidines
O
Outcome
Induction of naturally integrated C-type RNA virus
Inhibitors of protein synthesis induce naturally integrated C-type RNA virus in BALB/c mouse cells, providing a means to study gene regulation in mammalian cells.
Cite This Study
Aaronson et al. (1974) studied this question.