The cellular restriction to persistence of certain inducible endogenous type C viruses can be overcome in actively replicating cells, which may explain their high frequency in naturally occurring tumors.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for endogenous virus persistence in tumors; leaves open relevance to human cancers.
Cells of mouse and rat origin contain endogenous type C viruses. There are intrinsic regulatory factors which restrict the ability of different classes of these inducible viruses to persist in cells after chemical activation. The cellular block to certain viruses is shown to be overcome under conditions in which the virus-activated cells are allowed continued exponential growth. These findings may help to explain the high frequency at which replicating type C viruses are detectable in naturally occurring tumors of some species.
No takes yet. Share an insight, caveat, or question.
Aaronson et al. (1974) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: