What question did this study set out to answer?

This study aims to compare major amputation and all-cause mortality rates between patients with and without prior minor amputation in those with peripheral arterial disease.

June 20, 2026CureusOpen Access

Outcomes in Patients With Peripheral Arterial Disease With and Without Prior Minor Amputation: A Comparative Analysis

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Authors

RHRakibul HasanUniversity of Louisville NANur A Al AminBangabandhu Sheikh Mujib Medical University MMM Rejwane MahmudKettering General Hospital

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Implication

Retrospective cohort study compares amputation rates in patients with or without prior minor amputation, suggesting implications for treatment.

Key Points

This study aims to compare major amputation and all-cause mortality rates between patients with and without prior minor amputation in those with peripheral arterial disease.
Retrospective cohort study of 430 patients with peripheral arterial disease at a tertiary vascular center.
Patients were stratified into prior minor amputation (PMA) and non-PMA groups.
Statistical analyses included unpaired t-tests, chi-square tests, and Cox proportional hazards regression.
PMA patients had a lower adjusted risk of major amputation (HR 0.05, 95% CI 0.02-0.18, P=0.001) and all-cause mortality (HR 0.44, 95% CI 0.22-0.87, P=0.017).
Statin therapy was linked to reduced mortality risk (HR 0.21, 95% CI 0.10-0.43, P<0.001).
Revascularization was associated with increased mortality risk (HR 2.02, 95% CI 1.05-3.83, P=0.033).

Cite This Study

Hasan et al. (2026) studied this question.

synapsesocial.com/papers/6a362ebddb0793dc1a53669d https://doi.org/10.7759/cureus.111112

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Implication

Retrospective cohort study compares amputation rates in patients with or without prior minor amputation, suggesting implications for treatment.

Outcomes in Patients With Peripheral Arterial Disease With and Without Prior Minor Amputation: A Comparative Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Outcomes in Patients With Peripheral Arterial Disease With and Without Prior Minor Amputation: A Comparative Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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