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June 20, 2026DiagnosticsOpen Access

Adjunctive Value of Admission CBC-Derived Inflammation Indices for Catheter-Related Bloodstream Infection in Catheter-Dependent Hemodialysis Patients: A Retrospective Case–Control Study

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Authors

MCMuhammed Ali CoşkunerAntalya Bilim UniversityGKGökhan KökerAntalya Eğitim ve Araştırma HastanesiGKGülhan Özçelik KökerAkdeniz University

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Overview

Retrospective trial evaluates hematologic indices for identifying infection risk in hemodialysis patients, suggesting diagnostic aid.

Key Points

  • This research investigates the effectiveness of admission complete blood count-derived inflammation indices in identifying catheter-related bloodstream infection (CRBSI).
  • Single-center retrospective study from January 2011 to October 2024 including catheters-dependent hemodialysis patients.
  • Evaluated indices: NLR, LMR, PLR, SII, PIV from admission blood counts, compared CRBSI cases with non-infectious controls.
  • Discrimination assessed through ROC analysis and multivariable logistic regression for adjusted associations.
  • CRBSI patients had significantly higher NLR, SII, and PIV; lower LMR; PLR showed no difference.
  • NLR AUC 0.737 with sensitivity 68.7% and specificity 68.3% (p < 0.001); SII AUC 0.693, PIV AUC 0.686, both with moderate discrimination.
  • NLR remained significantly associated with CRBSI (OR 1.159; p < 0.001) alongside hypertension and cardiovascular disease.

Cite This Study

Coşkuner et al. (2026) studied this question.

synapsesocial.com/papers/6a362f11db0793dc1a53695fhttps://doi.org/10.3390/diagnostics16121907
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hematologic predictors of in-hospital mortality in chronic hemodialysis patients with catheter-related bloodstream infections2026
  2. 2Association Between Admission Complete Blood Count‐Derived Inflammatory Markers and Mortality in Neonatal Intensive Care Unit Patients: A Retrospective Observational Study2026
  3. 3#1818 Association of combined systemic inflammatory indices with the severity and outcome of tunnelled hemodialysis catheter-related bacteremia2024
  4. 4Neutrophil-to-lymphocyte ratio and CRP-to-albumin ratio in the prediction of catheter-related bloodstream infection among maintenance hemodialysis patients: a synergistical optimization algorithm2025
  5. 5Predictive value of complete blood cell count-based inflammatory markers for peritonitis risk in peritoneal dialysis patients: A multicenter cohort study2026