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September 14, 2026Journal of Paediatrics and Child HealthOpen Access

Association Between Admission Complete Blood Count‐Derived Inflammatory Markers and Mortality in Neonatal Intensive Care Unit Patients: A Retrospective Observational Study

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Authors

AÖAyberk ÖzkavaklıBÇBengisu ÇağlıaltuncuFFFatih Fakirullahoğlu

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Overview

Retrospective observational study reveals limited predictive value of admission blood count inflammatory markers for mortality in neonates, highlighting poor standalone clinical utility.

Key Points

  • To assess the association between admission complete blood count-derived inflammatory markers and in-hospital mortality in a neonatal intensive care unit population.
  • Retrospective observational study of neonates admitted to a mixed level II and III NICU between 2022 and 2026 (N = 530).
  • Calculated neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) from admission complete blood counts.
  • Evaluated associations with mortality using multivariable logistic regression and discrimination using receiver operating characteristic (ROC) analysis.
  • In-hospital mortality occurred in 45 of 530 neonates (8.5%), with nonsurvivors exhibiting significantly lower median SII and SIRI, whereas baseline NLR and PLR showed no significant differences.
  • After gestational age adjustment, PLR was significantly associated with mortality (aOR, 0.381; 95% CI, 0.151–0.960; p = 0.041), remaining significant after adjusting for early-onset sepsis (p = 0.039) but losing significance when adjusted for birth weight (p = 0.065).
  • All indices demonstrated poor standalone discrimination for mortality (AUC range, 0.517–0.609), with only SII reaching statistical significance (AUC, 0.609; 95% CI, 0.529–0.689; p < 0.01).

Cite This Study

Özkavaklı et al. (2026) studied this question.

synapsesocial.com/papers/6aa7b3bf0926e14a848b2f48https://doi.org/10.1111/jpc.70594
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