Dissolving Microneedles Loaded with Chitosan Oligosaccharides and Gallic Acid-Modified ε-Poly-L-lysine for the Combined Antibacterial and Anti-inflammatory Therapy of Acne Vulgaris

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Key Points

To investigate the effectiveness of dissolving microneedles loaded with chitosan oligosaccharides and gallic acid for treating acne vulgaris.
Developed microneedles incorporating chitosan oligosaccharides and gallic acid-modified ε-poly-L-lysine.
Evaluated antibacterial and anti-inflammatory properties through in vitro assays.
Assessed treatment efficacy in a clinical setting with acne vulgaris patients.
Significantly reduced P. acnes proliferation (p<0.01).
Improved inflammatory markers in treated areas, with a reduction of 30% (p<0.05).
Demonstrated greater patient satisfaction based on clinical assessment scores.

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Tests combined antibacterial and anti-inflammatory therapy in acne vulgaris, indicating effective treatment options.

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Du et al. (2026) studied this question.

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