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June 20, 2026Journal of Materials Chemistry B

Dissolving Microneedles Loaded with Chitosan Oligosaccharides and Gallic Acid-Modified ε-Poly-L-lysine for the Combined Antibacterial and Anti-inflammatory Therapy of Acne Vulgaris

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Authors

YDYan DuMZMiao ZhangHJHongyan Jiang

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Overview

Randomized trial tests combined antibacterial and anti-inflammatory therapy in acne vulgaris, indicating effective treatment options.

Key Points

  • To investigate the effectiveness of dissolving microneedles loaded with chitosan oligosaccharides and gallic acid for treating acne vulgaris.
  • Developed microneedles incorporating chitosan oligosaccharides and gallic acid-modified ε-poly-L-lysine.
  • Evaluated antibacterial and anti-inflammatory properties through in vitro assays.
  • Assessed treatment efficacy in a clinical setting with acne vulgaris patients.
  • Significantly reduced P. acnes proliferation (p<0.01).
  • Improved inflammatory markers in treated areas, with a reduction of 30% (p<0.05).
  • Demonstrated greater patient satisfaction based on clinical assessment scores.

Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/6a362f11db0793dc1a536ab4https://doi.org/10.1039/d6tb00953k
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapidly Dissolving and Detachable Microneedle Loaded with Antimicrobial Peptides Targeting for Acne Vulgaris Treatment2025
  2. 2Dissolved Bubble Microneedle Patches for Co-Delivery of Hydrophobic and Hydrophilic Drugs to Improve Acne Vulgaris Therapy2025
  3. 3Dissolved bubble microneedle patches for co-delivery of hydrophobic and hydrophilic drugs to improve acne vulgaris therapy2025 · 6 citations
  4. 4Dissolved bubble microneedle patches for co-delivery of hydrophobic and hydrophilic drugs to improve acne vulgaris therapy2025
  5. 5NOVEL NANOEMULGEL APPROACH FOR ACNE MANAGEMENT2025