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June 20, 2026MaterialsOpen Access

Crosslinker-Integrated Photocleavable Gelatin–PEG Hydrogel via Bioorthogonal SPAAC Chemistry for UV-Triggered On-Demand Degradation

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Authors

YKYeon Tae KangGPGayeon PyoKMKarthika Muthuramalingam

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Overview

Randomized trial demonstrates UV-triggered degradation in gelatin-PEG hydrogels, indicating a versatile approach for drug release applications.

Key Points

  • This research aims to develop a photocleavable gelatin-PEG hydrogel that allows for controlled degradation without compromising bioactivity.
  • Utilized strain-promoted azide-alkyne cycloaddition (SPAAC) for crosslinking hydrogels.
  • Synthesized acetylated gelatin-azide and four-arm PEG-PC-DBCO for hydrogel construction.
  • Tested hydrogel properties through FT-IR, NMR, UV-Vis spectroscopy, and rheological analyses.
  • Hydrogel displays elastic-dominant behavior (G' > G'') under physiological conditions.
  • Successful cleavage of the crosslinker and rapid dissolution upon 365 nm irradiation were observed.
  • Demonstrated potential for drug release applications and dynamic tissue engineering scaffolds.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/6a362f3bdb0793dc1a536b8ehttps://doi.org/10.3390/ma19122625
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