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June 20, 2026PLoS ONEOpen Access

Evaluation of steroids for acute COVID in the prevention of long COVID in children: An EHR and pediatric cohort study from the RECOVER Initiative

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Authors

KHKathryn HirabayashiVLVitaly LormanSWShannon Wuller

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Overview

Retrospective cohort study evaluates steroid effectiveness in preventing long COVID in children, suggesting limited impact.

Key Points

  • Evaluate the effectiveness of steroids in preventing long COVID in children during acute SARS-CoV-2 infection.
  • Retrospective cohort study using target trial emulation methodology.
  • Compared children receiving steroids to those who did not within 12 days of SARS-CoV-2 infection.
  • Analyzed primary and secondary outcomes using Cox proportional models.
  • In hospitalized children, steroid use reduced the risk of gastrointestinal PASC (HR: 0.58; 95% CI: 0.39–0.85, p=0.01).
  • No significant impact of steroid treatment on other PASC outcomes in hospitalized patients or outpatients.
  • Overall, steroids did not lead to a decreased risk of long COVID except for gastrointestinal issues.

Cite This Study

Hirabayashi et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a536f3dhttps://doi.org/10.1371/journal.pone.0350888
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