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June 20, 2026Journal of Cosmetic DermatologyOpen Access

Reviving the Skin From Within: Mechanistic Insights Into a Well‐Tolerated Dermal Filler— CPM ‐ HA20G

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Authors

KMKay MarquardtCHChristian HartmannSSSonja Sattler

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Overview

Preclinical trial investigates hydration mechanisms of CPM-HA20G in skin, demonstrating effective tolerability and integration.

Key Points

  • To investigate the hydration mechanisms and cell protection properties of CPM-HA20G, a dermal filler containing HA and glycerol.
  • Utilized primary normal human epidermal keratinocytes, in vitro skin, and ex vivo human skin models.
  • Conducted gene expression analysis, protein analysis, and cell-based assays.
  • Employed 3D micro-computed tomography, transepidermal water loss (TEWL), corneometry, and histology to assess treatment outcomes.
  • CPM-HA20G increased hydrated tissue volumes by 40% within 10 minutes and 63% after 120 minutes post-injection (p < 0.001).
  • Glycerol reduced oxidative stress markers in keratinocytes by 68% (p < 0.0001) and improved tissue integration compared to HA12.5S.
  • Glycerol enhanced hydration without upregulating AQP3 expression, contrasting with sorbitol and mannitol which increased cellular stress.

Cite This Study

Marquardt et al. (2026) studied this question.

synapsesocial.com/papers/6a362fe6db0793dc1a5373cbhttps://doi.org/10.1111/jocd.70996
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  4. 4Facial Skin Revitalization With <scp>CPM</scp> ‐ <scp>HA20G</scp> (Hyaluronic Acid + Glycerol): A Comparative Case Series Using Three Delivery Techniques With Ultrasound Confirmation2026
  5. 5Efficacy and Safety of a Stabilized Composition of 26 mg/mL of High Molecular Weight Hyaluronic Acid for Aesthetic Applications2025 · 2 citations