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This study investigates the anti-asthmatic effects of Aster tataricus and its underlying molecular mechanisms.

Elucidating the Potential Anti-asthmatic Mechanism of Aster tataricus by Combining Network Pharmacology with Experimental Validation in aMurine Model

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Randomized trial investigates the anti-asthmatic effects of Aster tataricus in a murine model, suggesting therapeutic potential for asthma treatment.

This study investigates the anti-asthmatic effects of Aster tataricus and its underlying molecular mechanisms.
Utilized an ovalbumin-induced murine model of allergic airway inflammation.
Assessed airway inflammation via histochemistry and quantified cytokines in BALF using ELISA.
Integrated network pharmacology and molecular docking to identify and validate targets and pathways.
Aster tataricus significantly reduced airway inflammation and fibrosis in treated mice.
Observed reduction in IL-4, IL-5, IL-13 levels, with increases in IL-10 and IFN-γ in BALF (p<0.05).
Network pharmacology identified key targets (e.g., EGFR, STAT3) and pathways (e.g., PI3K-Akt), with validation showing downregulation of these targets.

Zang et al. (2026) studied this question.

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Randomized trial investigates the anti-asthmatic effects of Aster tataricus in a murine model, suggesting therapeutic potential for asthma treatment.