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June 20, 2026International Journal of CancerOpen Access

Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study( NEURO ‐ GLOVE Trial)

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Authors

KBKadriye BaşkurtGUGalip Can UyarEYEnes Yeşilbaş

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Overview

Prospective self-controlled study shows compression reduces symptoms of neuropathy in women with gynecologic cancers, suggesting a cost-effective intervention.

Key Points

  • Evaluate the effectiveness of dual-site mechanical compression during chemotherapy on reducing CIPN.
  • Prospective, intraindividual, self-controlled design with 76 women undergoing carboplatin-paclitaxel treatment.
  • Compression applied to nondominant hand and ipsilateral lower limb, with contralateral limbs as controls.
  • CIPN assessed using CTCAE v5.0 and EORTC QLQ-CIPN20 at various intervals.
  • Moderate-to-severe CIPN observed less frequently in compression limbs than controls at Cycle 3 (35.5% vs. 53.9%; p = 0.001).
  • Significantly lower sensory scores in compression limbs compared to controls from end of treatment onward (EOT: 7.5 vs. 10.2; p < 0.001).
  • Dual-site compression was associated with reduced incidence and persistence of CIPN.

Cite This Study

Başkurt et al. (2026) studied this question.

synapsesocial.com/papers/6a36300ddb0793dc1a5374bfhttps://doi.org/10.1002/ijc.70601
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Limb compression therapy and chemotherapy-induced peripheral neuropathy in women with gynecologic cancers: A prospective self-controlled study (NEURO-GLOVE Trial)—Updated long-term analysis.2026
  2. 2Safety and Efficacy of Compression Therapy to Prevent Chemotherapy-Induced Peripheral Neuropathy in Lower Extremities of Breast Cancer Patients: A Pilot Study2024 · 3 citations
  3. 3Efficacy of Hand Cooling and Compression in Preventing Taxane-Induced Neuropathy2025 · 36 citations
  4. 4Efficacy of surgical glove-compression therapy as a prevention of paclitaxel-induced peripheral neuropathy: Randomized controlled trial.2026
  5. 5Combined Compression and Cooling Therapy for Taxane Chemotherapy-induced Peripheral Neuropathy in Lung Cancer2025 · 1 citations