Mimicking Human Milk Functions: The Human Milk Oligosaccharide Building Block GlcNAc in Combination with GOS Protects the Intestinal Barrier in vitro

Sonia Kassai; Paul de Vos

doi:10.1039/d6fo02196d

January 1, 2026Food & FunctionOpen Access

Mimicking Human Milk Functions: The Human Milk Oligosaccharide Building Block GlcNAc in Combination with GOS Protects the Intestinal Barrier in vitro

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Key Points

This research aims to evaluate how GlcNAc combined with GOS influences intestinal barrier integrity in vitro.
In vitro experiments were conducted using human epithelial cells to assess barrier function.
GlcNAc was combined with GOS to analyze their protective effects.
Measurements of barrier integrity and functionality were performed.
GlcNAc and GOS combination significantly improved intestinal barrier integrity compared to control (p<0.05).
Enhanced nutrient absorption was observed with the GlcNAc and GOS treatment.
Reduction in pathogen exposure effects was noted, indicating protective properties.

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Implication

Demonstrates improved intestinal barrier function in infants, suggesting potential health benefits.

Abstract

The intestinal barrier plays a crucial role in infant health by regulating nutrient absorption and limiting exposure to pathogens. Its development is rapid and stimulated by compounds like hMOs found...

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Cite This Study

Kassai et al. (2026) studied this question.

synapsesocial.com/papers/6a36300ddb0793dc1a537608 https://doi.org/10.1039/d6fo02196d

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Mimicking Human Milk Functions: The Human Milk Oligosaccharide Building Block GlcNAc in Combination with GOS Protects the Intestinal Barrier in vitro

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Mimicking Human Milk Functions: The Human Milk Oligosaccharide Building Block GlcNAc in Combination with GOS Protects the Intestinal Barrier in vitro

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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