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June 20, 2026Clinical and Translational Radiation OncologyOpen Access

Moving beyond anatomy: the future of rectal cancer management is biologically-informed, response-adapted, and patient-centered

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Authors

KJKrishan R. JethwaJSJ Joshua. SmithHSHanna Sanoff

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Overview

Correspondence discusses biologically-informed strategies for locally advanced rectal cancer management, suggesting improved outcomes by integrating patient preferences.

Key Points

  • The correspondence aims to challenge anatomy-centric frameworks in treating locally advanced rectal cancer and emphasize biologically-informed strategies.
  • Critique of recent review on anatomical treatment strategies for rectal cancer.
  • Discussion of curative-intent strategies regarding their trade-offs in outcomes.
  • Advocacy for integrating patient preferences and biological determinants into treatment decisions.
  • Contemporary treatment strategies show that total neoadjuvant therapy with organ preservation may lead to better functional outcomes compared to standard approaches.
  • Modern radiotherapy and organ preservation techniques yield favorable response rates and quality of life metrics.
  • Urgent call to prioritize biologic risk assessment and adaptive treatment in managing locally advanced rectal cancer.

Cite This Study

Jethwa et al. (2026) studied this question.

synapsesocial.com/papers/6a36306fdb0793dc1a537889https://doi.org/10.1016/j.ctro.2026.101214
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant Treatment for Locally Advanced Rectal Cancer: Current Status and Future Directions2025
  2. 2The Expansion of Curative Treatment Options for Locally Advanced Rectal Cancer as a Model for the Translation of Personalized Medicine2026
  3. 3Watch and wait in locally advanced rectal cancer: Evolution, current evidence, and future directions.2025 · 1 citations
  4. 4The multidisciplinary management of locally advanced rectal cancer2024 · 1 citations
  5. 5Advancing Personalized Medicine in the Treatment of Locally Advanced Rectal Cancer2024 · 3 citations