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June 20, 2026BMJ OpenOpen Access

Strategic Amyotrophic Lateral Sclerosis Australia–Systems Genomics Consortium (SALSA-SGC): cohort profile

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Authors

AHAnjali K. HendersLZLaura ZiserFGFleur C. Garton

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Overview

Cohort profile reports clinical data and biological samples from ALS cases and controls, suggesting insights for future research.

Key Points

  • The aim is to create a large, detailed cohort for studying ALS and its underlying mechanisms through clinical and biological data.
  • Established infrastructure for ALS research involving major Australian MND clinics.
  • Recruited 1813 participants from April 2016 to December 2024, including ALS cases, controls, and asymptomatic relatives.
  • Collected longitudinal clinical data and biospecimens, with ongoing recruitment efforts in regional Australia.
  • Identified 125 mutation carriers among screened ALS cases, including 70 with C9orf72 expansions.
  • Collected data include 4442 clinic visits and 3201 samples available for research.
  • Resources have been utilized by both national and international researchers for various studies.

Cite This Study

Henders et al. (2026) studied this question.

synapsesocial.com/papers/6a363123db0793dc1a5381cchttps://doi.org/10.1136/bmjopen-2025-110906
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Also Consider

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