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December 8, 2025PLoS ONEOpen Access

Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study

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Authors

HKHyungMo KangMBMathieu BlaisLBLiziane Bouvier

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Overview

Longitudinal observational study evaluates biomarkers and neurological examination in ALS, highlighting a novel biobank for research.

Key Points

  • The study aims to create a comprehensive understanding of ALS through detailed biosampling and data collection.
  • Prospective multicenter observational study involving individuals with ALS and healthy controls.
  • Collection of clinical information, neurological and cognitive examinations, speech recording, and advanced magnetic resonance imaging.
  • Establishment of a biobank for storing data and biosamples under an open science governance framework.
  • The study aims to enroll 120 participants with ALS and 50 healthy controls.
  • Four sites are currently operating, with recruitment of participants ongoing.

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d295https://doi.org/10.1371/journal.pone.0332430
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Strategic Amyotrophic Lateral Sclerosis Australia–Systems Genomics Consortium (SALSA-SGC): cohort profile2026
  2. 2The Feasibility and Acceptability of Sharing Video Recordings of Amyotrophic Lateral Sclerosis Clinical Encounters With Patients and Their Caregivers: Pilot Randomized Clinical Trial (Preprint)2024
  3. 3Research access barriers in amyotrophic lateral sclerosis2025
  4. 4Individualized phenotyping of functional amyotrophic lateral sclerosis pathology in sensorimotor cortex2026
  5. 5Multimodal strategies for diagnosis, stratification, and therapeutic monitoring in ALS2026